{"id":57085,"date":"2023-06-21T15:02:16","date_gmt":"2023-06-21T05:02:16","guid":{"rendered":"https:\/\/hudsonorgau.wpengine.com\/?post_type=hdsn_news_post&p=57085"},"modified":"2023-06-21T15:02:19","modified_gmt":"2023-06-21T05:02:19","slug":"how-inflammation-affects-brain-development","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/how-inflammation-affects-brain-development\/","title":{"rendered":"How inflammation affects brain development"},"content":{"rendered":"\n

It has long been recognised that too much inflammation in the womb can harm an unborn baby\u2019s brain development, but exactly how it happens has been a mystery\u2026until now.<\/p>\n\n\n

\n
\"Sharmony
L-R: Sharmony Kelly and Dr Robert Galinsky<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Dr Rob Galinsky<\/a> and his team at Hudson Institute of Medical Research focus on understanding the cellular and physiological processes that impair brain development and function in the fetus and newborn.<\/p>\n\n\n\n

Their latest research, published in the Journal of Neuroinflammation<\/em><\/a>, shows for the first time how inflammation changes nerve cell maturation and function.<\/p>\n\n\n\n

They showed that too much inflammation in the womb impairs the maturation of nerve cells (called neurons), leading to reduced electric activity.<\/p>\n\n\n\n

Neurons are the cells in our brain and spinal cord that receive and transmit electrical signals that control the way we walk, hear, see, and think.<\/p>\n\n\n\n

Brain development impacts<\/h2>\n\n\n\n

Lead researcher, Sharmony Kelly<\/a> says their findings will have a positive impact in preventing or reducing a wide range of conditions that can affect babies, especially those born preterm.<\/p>\n\n\n\n

\n

\u201cInflammation can lead to cerebral palsy<\/a> or developmental problems affecting growth, movement, vision and hearing, as well as social and emotional problems, language and cognitive delays and more,\u201d Ms Kelly said.<\/p>\n\n\n\n

\u201cBy increasing our understanding of exactly how inflammation damages brain development we hope to help prevent these life-long consequences.\u201d<\/p>\n<\/blockquote>\n\n\n\n

\u201cWe also showed that these impairments in nerve cell maturation can be detected using a relatively simple and widely used clinical tool that measures electrical activity in the brain, called electroencephalography,\u201d said Dr Galinsky.<\/p>\n\n\n\n

Delicate balance of brain development <\/h2>\n\n\n\n
\n

\u201cBy improving our understanding of the cellular mechanisms that contribute to inflammation-induced disturbances in brain development, and their functional consequences, we can improve our ability to detect neurodevelopment impairments earlier.\u201d<\/p>\n<\/blockquote>\n\n\n\n

Sharmony Kelly likened the impact of inflammation to a disruption in the symphony of brain development.<\/p>\n\n\n\n

\n

\u201cImagine the brain as an orchestra playing a melody of growth and connectivity; when it\u2019s exposed to inflammation, like an out-of-tune instrument, the orchestra’s performance becomes distorted.\u201d<\/p>\n<\/blockquote>\n\n\n\n

\u201cIf the delicate balance of brain activity, cellular growth, and immune responses is disrupted, potentially leading to long-lasting consequences.\u201d<\/p>\n\n\n\n

\u201cWe\u2019re drawing attention to the significance of maintaining a harmonious environment for healthy brain development and the potential consequences when that balance is disrupted,\u201d she said.<\/p>\n\n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n Cerebral Palsy | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

Collaborators |<\/strong> University of Auckland, Monash University<\/p>\n\n\n\n

Funders |<\/strong> NHMRC, Cerebral palsy alliance, Harold and Cora Brennan Benevolent Trust<\/p>\n\n\n\n

Contact us<\/strong><\/h3>\n\n\n\n

Hudson Institute communications
t: <\/strong>+ 61 3 8572 2761
e:<\/strong> communications@hudson.org.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

It has long been recognised that inflammation can harm an unborn baby\u2019s brain development, but exactly how it happens has been a mystery\u2026until now.…  Read more<\/a><\/p>\n","protected":false},"featured_media":57090,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[],"class_list":["post-57085","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery"],"acf":[],"yoast_head":"\nHow inflammation affects brain development | Hudson Institute<\/title>\n<meta name=\"description\" content=\"Inflammation can harm an unborn baby\u2019s or newborn's brain development, but exactly how it happens has been a mystery\u2026until now.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/how-inflammation-affects-brain-development\/\" \/>\n<meta property=\"og:locale\" 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