{"id":55237,"date":"2023-03-28T17:46:03","date_gmt":"2023-03-28T06:46:03","guid":{"rendered":"https:\/\/hudsonorgau.wpengine.com\/?post_type=hdsn_news_post&p=55237"},"modified":"2024-07-08T11:50:21","modified_gmt":"2024-07-08T01:50:21","slug":"t-cells-open-the-door-to-potential-immune-therapies","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/t-cells-open-the-door-to-potential-immune-therapies\/","title":{"rendered":"T cells open the door to potential immune therapies"},"content":{"rendered":"\n

Keeping T cells active, but not too active, could be the key to new potential immune therapies, according to the latest research.<\/p>\n\n\n\n

While T cells play a critical role in the immune system by protecting our body against infection and cancer, regulation of T cell activity is necessary to prevent excessive inflammation<\/a> and damage to healthy tissue.<\/p>\n\n\n\n

A team of researchers including Hudson Institute\u2019s Associate Professor Kate Lawlor<\/a> is investigating how the T cells\u2019 life and death is controlled and what molecular mechanisms are at play in the regulation of the T cells\u2019 activity.<\/p>\n\n\n\n

In a study published in the journal Cell Death and Disease<\/a>,<\/u><\/em> they worked with mucosal associated invariant T (MAIT) cells \u2013 a type of T cells that play a crucial role in protecting our bodies against bacterial infections.<\/p>\n\n\n\n

Potential immune therapies to control inflammation<\/strong><\/h2>\n\n\n\n

The researchers found that MAIT cells have a unique survival and death mechanism compared to other types of T cells.<\/p>\n\n\n\n

They discovered that a protein, called RIPK3 (Receptor-Interacting Protein Kinase 3), plays a crucial role in regulating MAIT cell numbers, but the same effect was not seen for other T cell populations.<\/p>\n\n\n\n

University of Melbourne\u2019s Dr Timothy Patton, a Research Officer at the Doherty Institute and a lead author of the study, explained.<\/p>\n\n\n\n

\u201cThe RIPK3 protein controls both inflammation and cell death activity. It is a master ‘decision maker’ controlling if a cell will die, and how much inflammation the cell will drive in both its life and death.\u201d<\/p>\n\n\n\n

\u201cIn MAIT cells, but not other T cells, RIPK3 plays more of a \u2018pro-death\u2019 role restricting the accumulation of MAIT cells normally.\u201d<\/p>\n\n\n\n

New therapeutic solutions<\/strong><\/h2>\n\n\n\n

Understanding more about how MAIT cells work opens the door to new therapeutic solutions to help fight infectious diseases.<\/p>\n\n\n\n

\u201cThese findings suggest RIPK3 is a good target to develop therapies that can either increase or decrease the activity of MAIT cells,\u201d said University of Melbourne\u2019s Associate Professor Alexandra Corbett,<\/a> Laboratory Head at the Doherty Institute and a senior author of the paper.<\/p>\n\n\n\n

\u201cThis could be useful for treating conditions where MAIT cell activity needs to be reduced, such as autoimmune diseases, or where it needs to be increased, such as bacterial infections.\u201d<\/p>\n\n\n\n

This research was carried out by a collaborative team of researchers at the Doherty Institute, Hudson Institute for Medical Research and the Walter and Eliza Hall Institute.<\/p>\n","protected":false},"excerpt":{"rendered":"

Keeping T cells active, but not too active, could be the key to new potential immune therapies, according to the latest research.…  Read more<\/a><\/p>\n","protected":false},"featured_media":55200,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[94],"class_list":["post-55237","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery","treatment-type-immunotherapies"],"acf":[],"yoast_head":"\nT cells open the door to potential immune therapies - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Researchers are working on regulation of T cell activity to prevent excessive inflammation and damage to healthy tissue.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/t-cells-open-the-door-to-potential-immune-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T cells open the door to potential immune therapies\" \/>\n<meta property=\"og:description\" content=\"Researchers are working on regulation of T cell activity to prevent excessive inflammation and damage to healthy tissue.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/t-cells-open-the-door-to-potential-immune-therapies\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-08T01:50:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2023\/03\/Dr-Kate-Lawlor-Doherty-News-story.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/t-cells-open-the-door-to-potential-immune-therapies\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/t-cells-open-the-door-to-potential-immune-therapies\\\/\",\"name\":\"T cells open the door to potential immune therapies - 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