{"id":52937,"date":"2022-10-13T10:22:48","date_gmt":"2022-10-12T23:22:48","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&#038;p=52937"},"modified":"2024-07-12T15:43:04","modified_gmt":"2024-07-12T05:43:04","slug":"modifying-gut-bacteria-to-treat-ibd","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/modifying-gut-bacteria-to-treat-ibd\/","title":{"rendered":"Modifying gut bacteria to treat IBD"},"content":{"rendered":"\n<p class=\"has-medium-font-size\">Hudson Institute\u2019s <a href=\"https:\/\/hudson.org.au\/researcher-profile\/samuel-forster\/\">Dr Samuel Forster<\/a> has received a highly prestigious fellowship to advance his work using the bacteria of the human microbiome to treat <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/inflammatory-bowel-disease\/\">Inflammatory bowel disease (IBD)<\/a>.<\/p>\n\n\n\n<p>IBD is a chronic, painful and disruptive inflammation of the lining of the gut. It affects about 130,000 Australians. Its cause is unknown, and it is incurable. Treatment involves expensive immune suppression that can have life changing side effects.<\/p>\n\n\n\n<p>Dr Samuel Forster will use his $1.25 million <a href=\"https:\/\/www.cslfellowships.com.au\/\" target=\"_blank\" rel=\"noreferrer noopener\">CSL Centenary Fellowship<\/a> to investigate the cause of IBD and open up new avenues for treatment. His team will apply genomics, computational biology, stem cells, and microbiomics, to answer fundamental questions about the immunology of the gut and its microbiome. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-safe-and-effective-ibd-treatments\">Safe and effective IBD treatments <\/h2>\n\n\n\n<p>His vision is to design safe and effective treatments for IBD.<\/p>\n\n\n\n<p>Hundreds of species of bacteria form the microbiome in our gut. Sam\u2019s work suggests that some of them influence the gut\u2019s immune system and contribute to the chronic inflammation that is IBD. But which species? Until recently it was impossible to grow and analyse these bacteria as a community.<\/p>\n\n\n\n<p>In 2016, working at the Sanger Institute in the UK, Sam was joint first author on a <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27144353\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Nature<\/em><\/a> paper that demonstrated that the vast majority of bacteria within the human microbiome could be cultivated using a single culture medium. In 2018, he returned to Hudson Institute where he applied the technique to grow communities of bacteria and analyse the microbiome of thousands of gut samples from hundreds of children being treated for IBD at the Monash Children\u2019s Hospital, working with paediatric gastroenterologist <a href=\"https:\/\/hudson.org.au\/researcher-profile\/edward-giles\/\">Dr Edward Giles<\/a>.<\/p>\n\n\n\n<p>\u201cWe have identified bacteria that appear to be blocking the normal, programmed death of cells lining the gut. This may be preventing resolution of inflammatory lesions in IBD,\u201d says Sam.<\/p>\n\n\n\n<p>Now Sam will study the interactions between these bacteria, the gut microbiome they\u2019re part of, and the genetic background of people with IBD.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" id=\"testing-potential-ibd-treatments\">Testing potential IBD treatments<\/h2>\n\n\n\n<p>His team will also grow \u2018mini guts-on-a-chip\u2019 that will allow him to test the effect of potential treatments.<\/p>\n\n\n\n<p>\u201cAbout 20 per cent of patients are diagnosed before the age of 20 and will suffer with this disease their entire adult lives,\u201d says Sam. \u201cSymptoms include cramping, abdominal pain, bloating, gas, diarrhea, and constipation. It\u2019s a nasty disease that can really hit people physically, emotionally, and socially.<\/p>\n\n\n\n<p>\u201cI hope this work will provide the basis for improved diagnosis, better targeting of conventional immunomodulatory therapies and completely new microbiome-based medicines that will all ultimately provide a better quality of life for people with IBD.\u201d<\/p>\n\n\n\n<p>\u201cWe know from recent clinical trials of faecal transplantation there\u2019s potential to modify the microbiome to treat IBD,\u201d he continues. \u201cBut these treatments only work for about 30 per cent of patients.&#8221;<\/p>\n\n\n\n<p>\u201cMy vision is to create safe and effective treatments that will improve quality of life for patients. Of the hundreds of bacterial species and thousands of bacterial strains only a handful have been developed for human application and, even then, primarily only as probiotics. We will explore and understand this treasure trove of bacteria to find ways to enable the microbiome of the gut to resist colonisation by harmful bacteria,\u201d he says. \u201cThese targeted microbial medicines would be living treatments tailored to suit the genetic predisposition of the patient and the unique characteristics of their microbiome.\u201d<\/p>\n\n\n\n    <div class=\"block--callout flex z-20 text-blue-800 bg-gray-100 p-6 mb-5 sm:mb-8 w-full\">\n        <div class=\"cms-content\">\n            <p><strong>READ MORE |\u00a0<\/strong><a href=\"https:\/\/hudson.org.au\/\/news\/ibd-causing-bacteria-discovered-in-mice\/\">IBD causing bacteria discovered in mice<\/a><\/p>\n        <\/div>\n    <\/div>\n\n    ","protected":false},"excerpt":{"rendered":"<p>Hudson Institute\u2019s Dr Samuel Forster has received a highly prestigious fellowship to advance his work using the bacteria of the human microbiome to treat Inflammatory bowel disease (IBD).&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/news\/modifying-gut-bacteria-to-treat-ibd\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":52929,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[87],"treatment-type":[95],"class_list":["post-52937","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-award","treatment-type-microbiome-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Modifying gut bacteria to treat IBD<\/title>\n<meta name=\"description\" content=\"Dr Sam Forster awarded prestigious CSL Fellowship to advance research using the bacteria of the human microbiome to treat IBD.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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