{"id":52393,"date":"2022-09-26T17:27:29","date_gmt":"2022-09-26T07:27:29","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&#038;p=52393"},"modified":"2023-12-14T16:11:22","modified_gmt":"2023-12-14T05:11:22","slug":"big-step-toward-slowing-emphysema","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/big-step-toward-slowing-emphysema\/","title":{"rendered":"Big step toward slowing emphysema"},"content":{"rendered":"\n<p class=\"has-medium-font-size\">Researchers are closer than ever to being able to turn off the actions of the immune system that damage the lungs \u2013 opening up the possibility of slowing emphysema development.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" id=\"at-a-glance\">At a glance<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story.jpg\" alt=\"Professor Brendan Jenkins works on being able to turn off the actions of the immune system that damage the lungs, opening up the possibility of slowing emphysema development.\" class=\"wp-image-52398\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story.jpg 600w, https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story-300x300.jpg 300w, https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story-150x150.jpg 150w, https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story-320x320.jpg 320w, https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/09\/Professor-Brendan-Jenkins-Emphysema-News-story-400x400.jpg 400w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption class=\"wp-element-caption\"><em>Professor Brendan Jenkins<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>Emphysema is a major cause of death worldwide<\/li>\n\n\n\n<li>Hudson Institute showed that inflammasomes promote emphysema development<\/li>\n\n\n\n<li>This could lead to new drug treatments slowing emphysema&#8217;s progression<\/li>\n<\/ul>\n\n\n\n<p>Emphysema is the major debilitating component of the lethal&nbsp;chronic obstructive pulmonary disease (COPD), which was the third leading cause of death worldwide in 2019, causing 3.23 million deaths.<\/p>\n\n\n\n<p>Researchers at Hudson Institute are investigating how uncontrolled activation of the immune system in the lung causes emphysema, and how to prevent it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-slowing-emphysema-progress\"><strong>Slowing emphysema progress<\/strong> <\/h2>\n\n\n\n<p>Professor Brendan Jenkins\u2019 research has revealed that a multiprotein complex of the innate immune system, called inflammasomes, promotes the development of emphysema.<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36037355\/\" target=\"_blank\" rel=\"noreferrer noopener\">His research<\/a>, as part of a team comprising Australian, German, Swiss and American researchers, is published in the prestigious journal <em><a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2201494119\" target=\"_blank\" rel=\"noreferrer noopener\">Procedures of the National Academy of Science (USA)<\/a><\/em>.<\/p>\n\n\n\n<p>Prof Jenkins said this opens the possibility of new emphysema treatments targeting the immune system, which could slow emphysema\u2019s progress in the lungs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" id=\"immune-based-emphysema-therapeutics\"><strong>Immune-based emphysema therapeutics<\/strong><\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cThese findings lay the foundation for the future design and clinical application of novel innate immune-based therapeutics against emphysema,\u201d he said.<\/p>\n\n\n\n<p>\u201cIt is significant research, because it\u2019s the first to demonstrate a specific pathological role for the AIM2 inflammasome in emphysema, in which we delineate a function for AIM2 in driving alveolar cell death in the lung that is independent of immune cell activity and inflammation.\u201d<strong>&nbsp;<\/strong><\/p>\n<\/blockquote>\n\n\n\n    <div class=\"block--callout flex z-20 text-blue-800 bg-gray-100 p-6 mb-5 sm:mb-8 w-full\">\n        <div class=\"cms-content\">\n            <p><strong>READ MORE |<\/strong> <a href=\"https:\/\/hudson.org.au\/\/news\/link-between-copd-emphysema-and-lung-cancer-could-lead-to-new-treatments\/\">Link between COPD, emphysema and lung cancer could lead to new treatments<\/a>.<\/p>\n        <\/div>\n    <\/div>\n\n    \n\n\n<h2 class=\"wp-block-heading\" class=\"wp-block-heading\" id=\"emphysema-facts\"><strong>Emphysema facts&nbsp;<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Emphysema is the major debilitating component of the lethal&nbsp;chronic obstructive pulmonary disease (COPD), which the World Health Organisation says was the third leading cause of death worldwide in 2019.<\/li>\n\n\n\n<li>Together, lung cancer and emphysema claim around 15,000 lives in Australia each year.<\/li>\n\n\n\n<li>Patients with emphysema are at an increased risk (between 25 and 30 per cent) of also developing lung cancer, the most lethal cancer in the world.<\/li>\n<\/ul>\n\n\n\n<p><strong>Collaborators | <\/strong>University of Melbourne, Monash Health, University Hospital of Geneva, National Cancer Institute (USA), RMIT University, Christian-Albrechts-University (Kiel, Germany).<\/p>\n\n\n\n<p><strong>Funders |<\/strong> <a href=\"https:\/\/www.nhmrc.gov.au\/funding\" target=\"_blank\" rel=\"noopener\">National Health and Medical Research Council (NHMRC)<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" class=\"wp-block-heading\" id=\"contact-us\"><span class=\"s1\"><b>Contact us<\/b><\/span><\/h3>\n\n\n\n<p><span class=\"s1\">Hudson Institute communications<br><b>t:&nbsp;<\/b>+ 61 3 8572 2761<br><b>e: <\/b><a href=\"mailto:communications@hudson.org.au\"><span class=\"s2\">communications@hudson.org.au<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers are closer than ever to being able to turn off the actions of the immune system that damage the lungs \u2013 opening up the possibility of slowing emphysema development.&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/news\/big-step-toward-slowing-emphysema\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":52398,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[94],"class_list":["post-52393","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery","treatment-type-immunotherapies"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Big step toward slowing emphysema -<\/title>\n<meta name=\"description\" content=\"A discovery of how the immune system causes emphysema has opened the possibility of a treatment slowing emphysema development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/big-step-toward-slowing-emphysema\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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