{"id":50334,"date":"2022-07-05T15:32:47","date_gmt":"2022-07-05T05:32:47","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&p=50334"},"modified":"2023-02-08T12:15:12","modified_gmt":"2023-02-08T01:15:12","slug":"rna-platelet-discovery-could-ease-load-on-blood-donors","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/rna-platelet-discovery-could-ease-load-on-blood-donors\/","title":{"rendered":"RNA platelet discovery could ease load on blood donors"},"content":{"rendered":"\n

A significant RNA platelet discovery has brought off-the-shelf blood transfusions a step closer. The discovery could help patients needing a transfusion of platelets, such as cancer patients undergoing chemotherapy.<\/p>\n\n\n

\n
\"Dr
Dr Minna-Liisa \u00c4nk\u00f6<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Platelets are the smallest of all blood cells; they circulate in the bloodstream and bind together when they recognise damaged blood vessels, making them a vital part of the body\u2019s response to bleeding.<\/p>\n\n\n\n

RNA regulatory protein discovered<\/h2>\n\n\n\n

Now researchers led by Dr Minna-Liisa \u00c4nk\u00f6<\/a> at Hudson Institute and Prof Susie Nilsson<\/a>, Research Director for Biomedical Manufacturing at Australia\u2019s national science agency CSIRO, have discovered a protein which is crucial to the role RNA regulatory plays in the production of platelets.<\/p>\n\n\n\n

Their latest research, published in the prestigious journal, Blood<\/a><\/em>, gives hope that one day platelets may be able to be manufactured, reducing the reliance on blood donations for transfusions to cancer<\/a> patients, among other uses.<\/p>\n\n\n\n

\u201cWe were able to characterise in molecular detail the cell that is best at making platelets and show that in the absence of this protein (serine-arginine rich splicing factor 3, or SRSF3) these efficient platelet producers were absent,\u201d Dr \u00c4nk\u00f6 said.<\/p>\n\n\n\n

RNA platelet discovery informing new treatments<\/h2>\n\n\n\n

Platelets carry no DNA, but they do carry RNA, and SRSF3 defines the types of RNA that are present.<\/p>\n\n\n\n

\n

\u201cThe protein, SRSF3, is like a designer that plans how the RNA landscape of these cells looks. A good design is also functional, and similarly the correct RNA landscape enables the functions of these cells,\u201d she said.<\/p>\n<\/blockquote>\n\n\n\n

\u201cIt\u2019s a really significant discovery, because RNA is emerging as a powerful and easily adaptable therapeutic molecule, as seen by the rapid development of effective mRNA vaccines, and it also has many potential diagnostic uses as well,” Dr Anko said.<\/p>\n\n\n\n

\u201cHowever, we need a detailed knowledge of RNA regulatory in cells in order to realise the full potential of RNA-based therapeutic and diagnostic uses,\u201d she said.<\/p>\n\n\n\n

This is the type of discovery that could inform major new treatments in the years to come.<\/p>\n\n\n\n

\n

\u201cUnderstanding which cells are best at producing platelets could make it possible for them to be manufactured in vitro without the need for blood donors,\u201d  Dr \u00c4nk\u00f6 said.<\/p>\n<\/blockquote>\n\n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n Cancer | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

Contact us<\/b><\/span><\/h3>\n\n\n\n

Hudson Institute communications
t: <\/b>+ 61 3 8572 2761
e: <\/b>communications@hudson.org.au<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A new insight into RNA regulation has taken researchers a big step forward in understanding how the body creates platelets.…  Read more<\/a><\/p>\n","protected":false},"featured_media":50342,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[92],"class_list":["post-50334","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery","treatment-type-cell-therapies"],"acf":[],"yoast_head":"\nRNA platelet discovery could ease load on blood donors - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"An RNA platelet discovery has brought off-the-shelf blood transfusions closer, helping patients like those undergoing chemotherapy for cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/rna-platelet-discovery-could-ease-load-on-blood-donors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RNA platelet discovery could ease load on blood donors\" \/>\n<meta property=\"og:description\" content=\"An RNA platelet discovery has brought off-the-shelf blood transfusions closer, helping patients like those undergoing chemotherapy for cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/rna-platelet-discovery-could-ease-load-on-blood-donors\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-08T01:15:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/05\/Dr-Minni-Anko-RNA-News-story.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"601\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/rna-platelet-discovery-could-ease-load-on-blood-donors\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/rna-platelet-discovery-could-ease-load-on-blood-donors\\\/\",\"name\":\"RNA platelet discovery could ease load on blood donors - 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