{"id":49255,"date":"2022-05-09T18:00:09","date_gmt":"2022-05-09T08:00:09","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&p=49255"},"modified":"2023-12-14T16:14:28","modified_gmt":"2023-12-14T05:14:28","slug":"filling-the-gaps-in-immune-system-cancer-research","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/filling-the-gaps-in-immune-system-cancer-research\/","title":{"rendered":"Filling the gaps in immune system cancer research"},"content":{"rendered":"\n

New light has been shone on the role of specific protein components of the immune system in both causing and preventing cancer.<\/p>\n\n\n

\n
\"Professor<\/a>
Professor Brendan Jenkins<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

In the most extensive review of its kind, published in Nature Reviews Cancer<\/em><\/a>, Professor Brendan Jenkins has analysed all available studies on innate immune pattern recognition receptors (PRRs) \u2013 the critical regulators of the immune system response to microbial infection and host tissue damage.<\/p>\n\n\n\n

His analysis is important in light of recent studies showing that in many cancer types, PRRs play a central role in modulating tumour-inhibiting and tumour-promoting cellular responses, both in immune cells within tumours and directly in cancer cells.<\/p>\n\n\n\n

New immune-based cancer drugs<\/h2>\n\n\n\n

Professor Jenkins believes this opens the potential to target PRRs for new immune-based biomarkers and therapeutics (drugs) to be developed for improved diagnosis and treatments for cancer patients.<\/p>\n\n\n\n

\n

\u201cFor the first time there is a comprehensive review and perspective on all PPRs in all cancers, including their potential targeting,\u201d he said.<\/p>\n\n\n\n

\u201cThere is a broad spectrum of innate immune PPRs with the potential to either inhibit or promote the growth of tumors, so there are opportunities to develop anti-cancer drugs that either augment or block their activation in a large range of cancers.<\/p>\n\n\n\n

\u201cWorking with Professor Si Ming Man<\/a> from the Australian National University, our review also summarises many of the previous and current clinical trials in cancer involving PPR inhibitors or activators,\u201d Professor Jenkins said.<\/p>\n<\/blockquote>\n\n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n Cancer | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

Collaborators | <\/strong>Professor Si Ming Man \u2013 Division of Immunity, Inflammation and Infection, The John Curtin School of Medical Research; The Australian National University, Canberra, Australian Capital Territory, Australia<\/p>\n\n\n\n

Contact us<\/strong><\/p>\n\n\n\n

Hudson Institute communications
t: <\/strong>+ 61 3 8572 2761
e: <\/strong>communications@hudson.org.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

New light has been shone on the role of specific protein components of the immune system in both causing and preventing cancer.…  Read more<\/a><\/p>\n","protected":false},"featured_media":49468,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[],"class_list":["post-49255","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery"],"acf":[],"yoast_head":"\nFilling the gaps in immune system cancer research - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"First comprehensive review of the immune system response in both causing and preventing cancer has been explained by researchers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/filling-the-gaps-in-immune-system-cancer-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Filling the gaps in immune system cancer research\" \/>\n<meta property=\"og:description\" content=\"First comprehensive review of the immune system response in both causing and preventing cancer has been explained by researchers.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/filling-the-gaps-in-immune-system-cancer-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-14T05:14:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2022\/05\/Prof-Brendan-Jenkins-Immune-System-News-story-2022.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/filling-the-gaps-in-immune-system-cancer-research\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/filling-the-gaps-in-immune-system-cancer-research\\\/\",\"name\":\"Filling the gaps in immune system cancer research - 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