{"id":43982,"date":"2021-11-29T10:27:22","date_gmt":"2021-11-28T23:27:22","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&p=43982"},"modified":"2024-09-10T11:05:23","modified_gmt":"2024-09-10T01:05:23","slug":"childrens-brain-cancer-project","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/childrens-brain-cancer-project\/","title":{"rendered":"Cataloguing brain cancer in children \u2013 Hudson Institute celebrates funding"},"content":{"rendered":"\n

An ambitious project to identify and characterise the rarest and deadliest forms of brain cancer in children<\/a> has received a welcome funding boost.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

Thanks to a generous grant from the Robert Connor Dawes Foundation<\/a>, Associate Professor Ron Firestein<\/a> and his team at Hudson Institute will spend the next two years establishing a unique catalogue of low-survival brain cancer in children.<\/p>\n\n\n\n

Adding to their impact, they then intend to share this resource with researchers worldwide, to accelerate the search for cures and treatments.<\/p>\n\n\n\n

The Robert Connor Dawes Foundation was created in 2013 in the memory of Robert \u2018Connor\u2019 Dawes, who died aged 18, after battling brain cancer for 16 months. It raises funds in Australia and the USA, reflecting Connor\u2019s dual nationalities.<\/p>\n\n\n\n

The foundation is battling paediatric brain tumours and supporting brain matters in the areas of research, care and development \u2013 to fund the science to end brain cancer and support patients in the meantime.<\/p>\n\n\n\n

A\/Prof Firestein\u2019s research aims to find new therapeutic targets: \u201cThere is a clear need to go beyond genomic sequencing to identify new targeted therapies for paediatric cancers of poorest survival.\u201d<\/p>\n\n\n\n

\u201cChildhood brain cancers comprise a diverse disease set that requires detailed molecular phenotyping and genomic sequencing to comprehensively catalogue,\u201d A\/Prof Firestein said.<\/p>\n\n\n\n

\u201cSo there is an urgent need to progress the characterisation of these low-survival tumours through molecular phenotyping of patient models that recapitulate the disease.<\/p>\n\n\n\n

\u201cThis is an exciting opportunity to extend our work with Dr Adam Resnick and the Children’s Brain Tumor Network (CBTN) team, to generate patient avatar models and fully characterise rare, but lethal, forms of childhood brain tumours.”<\/p>\n\n\n\n

Thanks to a grant of $235,494 over two years from the RCD Foundation, that work is now under way.<\/p>\n\n\n\n

\n \n
\n\n \n
\n\n \n
\n
\n \"Associate <\/div>\n
\n

Mapping Functional Genomic Dependencies for Rare Brain Cancer in Children<\/h3>\n \n

Associate Professor Ron Firestein<\/h4>\n <\/a>\n
\n
\n

Robert Connor Dawes Foundation 2022\u20132024<\/p>\n <\/div>\n

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Amount: $235,494<\/p>\n <\/div>\n

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Co-investigators:<\/strong> The Children’s Brain Tumor Network (CBTN)<\/p>\n <\/div>\n <\/div>\n

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Brain tumours are the most common and deadliest malignancy in children. Current precision medicine programs focus on genomic sequencing to identify discrete mutations that may predict patients\u2019 responses to targeted therapies. Unfortunately, fewer than 20 per cent of cancer patients harbour actionable mutations and of those who do, only 50 per cent respond to therapy. This underscores a clear need to go beyond genomic sequencing to identify new targeted therapies for paediatric cancers of poorest survival.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n","protected":false},"excerpt":{"rendered":"

An ambitious project to identify and characterise the rarest and deadliest forms of brain cancer in children has received a welcome funding boost.…  Read more<\/a><\/p>\n","protected":false},"featured_media":39892,"menu_order":0,"template":"page-templates\/template-fellowships-grants.php","issue":[],"tag":[],"story-type":[87],"treatment-type":[],"class_list":["post-43982","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-award"],"acf":[],"yoast_head":"\nCataloguing brain cancer in children \u2013 Hudson Institute celebrates funding - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"An ambitious project to identify and characterise the deadliest forms of children's brain cancer has received RCD Foundation funding.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/childrens-brain-cancer-project\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cataloguing brain cancer in children \u2013 Hudson Institute celebrates funding\" \/>\n<meta property=\"og:description\" content=\"An ambitious project to identify and characterise the deadliest forms of children's brain cancer has received RCD Foundation funding.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/childrens-brain-cancer-project\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-10T01:05:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2021\/09\/Ron-Firestein-scaled-e1649771831575.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/childrens-brain-cancer-project\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/childrens-brain-cancer-project\\\/\",\"name\":\"Cataloguing brain cancer in children \u2013 Hudson Institute celebrates funding - 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