{"id":37368,"date":"2021-04-30T16:37:23","date_gmt":"2021-04-30T06:37:23","guid":{"rendered":"https:\/\/hudson.org.au?post_type=hdsn_news_post&p=37368"},"modified":"2022-06-20T16:06:16","modified_gmt":"2022-06-20T06:06:16","slug":"preparing-for-the-next-pandemic","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/preparing-for-the-next-pandemic\/","title":{"rendered":"Preparing for the next pandemic"},"content":{"rendered":"\n

Leading virus scientist, Associate Professor Michelle Tate explains why new treatments are needed alongside vaccines.<\/p>\n\n\n\n

\"Associate
Associate Professor Michelle Tate<\/em><\/figcaption><\/figure><\/div>\n\n\n\n

A\/Prof Michelle Tate<\/a> is a world-leading expert in influenza<\/a> and innate immune responses. Michelle\u2019s research is focused on finding new treatments to help patients with severe COVID-19<\/a> and viral infections like influenza. She has spent much of her career researching hyperinflammation and severe disease, particularly during influenza A virus infection.<\/p>\n\n\n\n

In 2017<\/span><\/a>, Michelle predicted a future pandemic remarkably similar to COVID-19. She hopes to develop drugs to fight hyperinflammation in time for what she believes will be the next pandemic \u2013 influenza.<\/p>\n\n\n\n

Michelle is one of more than 100 leading inflammation researchers at Hudson Institute \u2013 the largest group in Australia \u2013 who could accelerate this vital research.<\/p>\n\n\n\n

Here, Michelle explains why this is so important.<\/p>\n\n\n\n

Tell us a bit about your influenza (flu) research<\/b><\/h3>\n\n\n\n

My expertise is in influenza research and how we can develop drugs to target our body\u2019s damaging inflammation to help limit life-threatening disease.<\/p><\/blockquote>\n\n\n\n

Inflammation is important because it helps remove infection from our system. However, during severe or fatal disease our immune system overreacts, resulting in hyperinflammation.<\/p>\n\n\n\n

We are working out the difference between an immune response that’s beneficial, versus one that is actually detrimental, causing disease.<\/p>\n\n\n\n

Can you describe the kinds of drugs needed?<\/b><\/h3>\n\n\n\n

When the next pandemic hits, we need to have cost-effective drugs that can be administered easily, don\u2019t cause severe side effects and could be broadly used for any virus and on any age group.<\/p>\n\n\n\n

You\u2019ve been predicting another pandemic \u2013 what do you think it will be? <\/b><\/h3>\n\n\n\n

It’s really hard to predict exactly what the next pandemic virus will be. COVID-19 was unexpected, but I think the next pandemic will most likely be a form of bird flu. Highly pathogenic influenza viruses currently circulate in wild birds and they have infected humans with mortality rates as high as 60 per cent. It is only a matter of time until bird flu acquires the ability to spread through our community.<\/p>\n\n\n\n

We actually don’t have any drugs available that we can use to treat severe flu. We would have to make a new vaccine, which would take time, so we really need drugs that we can use to treat the disease in the time between when the pandemic starts, and when a vaccine is ready.<\/p>\n\n\n\n

Why is inflammation so important during coronavirus infection? What does this mean for new pandemics? <\/b><\/h3>\n\n\n\n

W<\/span>hile my research is in influenza, there are many similarities with COVID, and the outcomes could provide treatments for any pandemic-type disease caused by hyperinflammation – such as COVID-19 and its aftermath, \u2018long COVID\u2019.<\/p>\n\n\n\n

We\u2019re just starting to understand long COVID and the long-term and potentially permanent health issues seen in some patients. These are, at least in part, likely due to the inflammatory damage caused by the immune response to COVID infection.<\/p>\n\n\n\n

Research on the inflammatory response to this, and other pandemic viruses is critical to finding new treatments to limit the impact of severe viral infections.<\/p>\n\n\n\n

New study identifies influenza treatment<\/h3>\n\n\n\n

\u201cThe Viral Immunity and Immunopathology laboratory at Hudson Institute is unravelling why people get very sick from the flu. Specifically, we are examining the mechanisms involved in inducing a damaging hyperinflammatory response, and how this can be dampened with new drugs to treat the disease,\u201d Michelle says.
<\/span><\/p>

\u201cOur recent study has identified a highly inflammatory cytokine called IL-1\u03b2 which <\/span>promotes hyperinflammation and is a potential therapeutic target for influenza. While previous studies have detected high levels of IL-1\u03b2<\/span> in the lungs of infected patients, our study was the first to specifically demonstrate IL-1\u03b2<\/span> plays a detrimental role in promoting severe influenza disease.\u201d<\/p><\/blockquote>\n\n\n\n

The study was published in the journal Immunology and Cell Biology<\/i><\/span><\/a>.<\/p>\n\n\n\n

\n
\n

What is inflammation?<\/b><\/h3>\n

Aside from COVID-19, inflammation underlies many diseases including long-term inflammatory illnesses such as rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis. Inflammation is also a major contributing factor in the development of many other common diseases such as cancer, diabetes, heart disease and stroke.<\/p>\n <\/div>\n <\/div>\n\n \n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n Influenza | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n COVID-19 | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

Contact us<\/b><\/span><\/h4>\n\n\n\n

Hudson Institute communications
t:\u00a0<\/b>+ 61 3 8572 2761
e:<\/b>\u00a0communications@hudson.org.au<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Leading virus scientist, Associate Professor Michelle Tate explains why new treatments are needed alongside vaccines.…  Read more<\/a><\/p>\n","protected":false},"featured_media":37367,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[],"treatment-type":[],"class_list":["post-37368","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nPreparing for the next pandemic - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Leading virus scientist, Assoc. 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