{"id":36917,"date":"2021-04-11T19:09:28","date_gmt":"2021-04-11T09:09:28","guid":{"rendered":"https:\/\/hudson.org.au?post_type=disease&#038;p=36917"},"modified":"2026-04-14T14:56:56","modified_gmt":"2026-04-14T04:56:56","slug":"testicular-cancer","status":"publish","type":"disease","link":"https:\/\/hudson.org.au\/disease\/cancer\/testicular-cancer\/","title":{"rendered":"Testicular cancer"},"content":{"rendered":"\n<div class=\"block bd-grid-container bd-grid-container--white bd-grid-container--layout-2-col-33-67 w-full max-w-screen h-full\">\n    <div class=\"relative flex h-full items-center pt-20 md:pt-28 lg:pt-36 pb-20 md:pb-28 lg:pb-36 hn-container mx-auto px-5 md:px-8 xl:px-12\">\n        <div class=\"bd-grid-container__innerblocks w-full grid grid-cols-4 sm:grid-cols-12 gap-10 bd-grid-container-layout--2-col-33-67\">\n\n<div class=\"bd-grid-container__column flex w-full col-span-4 sm:col-span-4            \">\n    <div class=\"w-full wp-block-bd-grid-container-column\">\n        <div class=\"grid-container-column__innerblocks cms-content\n                            \">\n\n<h2 class=\"wp-block-heading has-text-align-left\" id=\"h-testicular-cancer\">Testicular cancer<\/h2>\n\n\n\n<p class=\"has-medium-font-size\">The incidence of testicular cancer is rising worldwide at two per cent per year for the last 50 years, for unknown reasons. Younger men, aged between 20 and 40 years, have the highest risk of developing testicular cancer, the second most common cancer in this age group.<\/p>\n\n<\/div>\n    <\/div>\n<\/div>\n\n\n\n<div class=\"bd-grid-container__column flex w-full col-span-4 sm:col-span-8            \">\n    <div class=\"w-full wp-block-bd-grid-container-column\">\n        <div class=\"grid-container-column__innerblocks cms-content\n                            \">\n\n    <div class=\"block-faqs mb-12\">\n        \n            <div class=\"faq w-full flex flex-col bg-gray-100 mb-1\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_5e7847b42b373776122785bcba57b3f2-answer-1\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"what-is-testicular-cancer\">What is testicular cancer?<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_5e7847b42b373776122785bcba57b3f2-answer-1\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p>Testicular cancer appears as a painless hard lump or swelling on a testicle, part of a man\u2019s reproductive system. It can be a lump, the size of pea or much larger. The lump is a growth or tumour formed by abnormal cells that have multiplied. Most testicular lumps are not cancer.<\/p>\n<h4 id=\"what-are-the-types-of-testicular-cancer\"><strong>What are the types of testicular cancer?<\/strong><\/h4>\n<p>There are different types of testicular cancer, depending on which type of cell the cancer starts in. Testicular cancers from reproductive cells are the most common. These are called testicular germ cell tumours.<\/p>\n<p>Ninety-five per cent of testicular cancers are germ cell tumours, starting in the so called \u2018germ cells\u2019 that normally develop into sperm. There are two main sub-types of germ cell tumours:<\/p>\n<ul>\n<li>Non-seminoma tumours mostly occur in younger men aged from their late teens to early 20s. These tumours grow more quickly.<\/li>\n<li>Seminoma tumours usually occur in men aged 25-45 years, and are slower growing.<\/li>\n<\/ul>\n                    <\/div>\n\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-gray-100 mb-1\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_5e7847b42b373776122785bcba57b3f2-answer-2\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"what-causes-testicular-cancer\">What causes testicular cancer?<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_5e7847b42b373776122785bcba57b3f2-answer-2\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p>The specific causes of testicular cancer are not known, though it most commonly arises when the cells that normally develop into sperm in adult men, the reproductive cells, remain undeveloped. Some factors that increase the likelihood of developing testicular cancer include<\/p>\n<ul>\n<li>Family history<\/li>\n<li>Undescended testicle as an infant<\/li>\n<li>Infertility<\/li>\n<li>Having cancer in one testicle makes it more likely to develop in the other.<\/li>\n<\/ul>\n                    <\/div>\n\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-gray-100 mb-1\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_5e7847b42b373776122785bcba57b3f2-answer-3\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"how-is-testicular-cancer-diagnosed-and-treated\">How is testicular cancer diagnosed and treated?<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_5e7847b42b373776122785bcba57b3f2-answer-3\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p>A doctor will perform a physical examination. Other tests include ultrasound, blood, CT or MRI scan and surgery.<\/p>\n<p>Testicular cancer is one of the most treatable cancers. Treatment depends on the how far the cancer has advanced or its stage.<\/p>\n<p>Stage 1 | the cancer is only in the testicle.<br \/>\nStage 2 | the cancer has spread to pelvic region or stomach lymph nodes.<br \/>\nStage 3 | the cancer has spread to other areas of the body.<\/p>\n<p>Treatment at stage 1 is removal of the testicle, while stages 2 and 3 may include chemotherapy and\/or radiation.<\/p>\n<p>While 95 per cent of men who get testicular germ cell tumours can be cured, the prognosis or outlook is poor for men who relapse.<\/p>\n                    <\/div>\n\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-gray-100 mb-1\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_5e7847b42b373776122785bcba57b3f2-answer-4\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"testicular-cancer-and-male-infertility\">Testicular cancer and male infertility<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_5e7847b42b373776122785bcba57b3f2-answer-4\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p>While the survival rates from testicular cancer are excellent, with a 90 per cent cure rate, it can still have life-long consequences that include lower fertility and a higher risk of poor health in older age. In 2020, 928 Australian men were diagnosed with testicular cancer and 30 died from the disease.<\/p>\n<p>Importantly, researchers have linked testicular cancer with male infertility.<\/p>\n                    <\/div>\n\n                                    <\/div>\n            <\/div>\n                <\/div>\n\n\n<\/div>\n    <\/div>\n<\/div>\n\n<\/div>\n    <\/div>\n<\/div>\n\n\n\n<div class=\"block bd-grid-container bd-grid-container--grey bd-grid-container--layout-2-col-67-33 w-full max-w-screen h-full\">\n    <div class=\"relative flex h-full items-center pt-20 md:pt-28 lg:pt-36 pb-20 md:pb-28 lg:pb-36 hn-container mx-auto px-5 md:px-8 xl:px-12\">\n        <div class=\"bd-grid-container__innerblocks w-full grid grid-cols-4 sm:grid-cols-12 gap-10 bd-grid-container-layout--2-col-67-33\">\n\n<div class=\"bd-grid-container__column flex w-full col-span-4 sm:col-span-8            \">\n    <div class=\"w-full wp-block-bd-grid-container-column\">\n        <div class=\"grid-container-column__innerblocks cms-content\n                            \">\n\n<h2 class=\"wp-block-heading has-text-align-left\" id=\"h-our-testicular-cancer-research\">Our testicular cancer research<\/h2>\n\n\n\n<p class=\"has-text-align-left\">Discovering the processes required to make healthy sperm is essential knowledge for reversing the rising incidence of testicular cancer and infertility rates, and for developing treatments to combat these.<\/p>\n\n\n\n    <div class=\"block-faqs mb-12\">\n        \n            <div class=\"faq w-full flex flex-col bg-white border-b-4 border-pink-500 shadow-lg-center mb-2\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_3952762594e511decb33f7069055363e-answer-1\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"understanding-why-disrupting-testis-development-can-increase-testicular-risk\">Understanding why disrupting testis development can increase testicular risk <\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 rotate-0\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_3952762594e511decb33f7069055363e-answer-1\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 block\">\n                    <div class=\"cms-content\">\n                        <p><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-23567 alignleft\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg\" alt=\"Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute\" width=\"150\" height=\"150\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg 150w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-1000x1000.jpg 1000w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-320x320.jpg 320w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-400x400.jpg 400w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<p><strong>Molecular studies<\/strong>. Professor Kate Loveland is identifying the windows of development, from fetal life through to puberty, in which male reproductive function can be affected by environmental exposures that have consequences which reduce adult male fertility or health.\u00a0 The cells in a man\u2019s testis that form one thousand sperm per heartbeat originate in the developing fetus and go through many transitions before they turn into swimming cells which can penetrate an egg and start a new life. The team\u2019s research is uncovering the specific times and ways during transformation from a progenitor into a sperm when things can go wrong. In the case of testicular germ cell tumours, the first incidence occurs in the fetus, when something occurs to probably a few cells to stop them from maturing normally. They remain undetected until puberty when hormonal changes cause the cells to change into tumours.<\/p>\n                    <\/div>\n\n                                            <div class=\"related_researchers\">\n                            <ul class=\"flex flex-wrap mt-4 -mb-1\">\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Kate Loveland<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/mark-hedger\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Mark Hedger<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/patrick-western\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Patrick Western<\/span><\/a><\/li>\n                                                            <\/ul>\n                        <\/div>\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-white border-b-4 border-pink-500 shadow-lg-center mb-2\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_3952762594e511decb33f7069055363e-answer-2\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"male-fertility-and-testicular-cancer\">Male fertility and testicular cancer <\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_3952762594e511decb33f7069055363e-answer-2\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-20492 alignleft\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/06\/re193_Kate-Loveland_20180215-150x150.jpg\" alt=\"Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute\" width=\"150\" height=\"150\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/06\/re193_Kate-Loveland_20180215-150x150.jpg 150w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/06\/re193_Kate-Loveland_20180215-1000x1000.jpg 1000w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/06\/re193_Kate-Loveland_20180215-320x320.jpg 320w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/06\/re193_Kate-Loveland_20180215-600x600.jpg 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<p><strong>Molecular studies<\/strong>. Professor Loveland discovered the importance of a key cell signaling molecule, activin A, that is crucial for normal embryonic development and adult health, male fertility and testis cancer. By studying its actions during sperm development, this research revealed that activin A signals are altered in the germ cells that turn into tumour cells, instead of forming sperm, in the human testis. The discovery revealed that activin A is important for normal male fertility and may be suitable target for treatments in men with testicular cancer.\u00a0 Current research is investigating how different cells within the testis respond to disturbances that affect activin A signalling during fetal and infant life. The goal is to find new ways to limit the incidence of these tumours and reduce the risk of relapse.<\/p>\n                    <\/div>\n\n                                            <div class=\"related_researchers\">\n                            <ul class=\"flex flex-wrap mt-4 -mb-1\">\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Kate Loveland<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/sarah-moody\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Dr Sarah Moody<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/penny-whiley\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Penny Whiley Ph.D.<\/span><\/a><\/li>\n                                                            <\/ul>\n                        <\/div>\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-white border-b-4 border-pink-500 shadow-lg-center mb-2\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_3952762594e511decb33f7069055363e-answer-3\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"the-yin-and-yang-of-testicular-immune-cells\">The yin and yang of testicular immune cells<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_3952762594e511decb33f7069055363e-answer-3\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-23567 alignleft\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg\" alt=\"Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute\" width=\"150\" height=\"150\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg 150w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-1000x1000.jpg 1000w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-320x320.jpg 320w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-400x400.jpg 400w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<p><strong>Molecular studies<\/strong>. Professor Loveland\u2019s team is exploring the roles of immune cells in normal testis development and how they contribute to testis pathologies, including influencing the progression of testicular germ cell tumours. The team has identified changes in the frequency, distribution and identity of immune cells during fetal testis development when these tumours can form, and as the tumours develop in the testes of adult men.\u00a0 Ongoing studies are characterising the molecular signatures of these cells to learn how they \u2018talk\u2019 to each other, as the team has shown germ cell tumours can produce factors that stop immune cells from fighting off foreign cancer cells, so that they instead support tumour spread.<\/p>\n                    <\/div>\n\n                                            <div class=\"related_researchers\">\n                            <ul class=\"flex flex-wrap mt-4 -mb-1\">\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Kate Loveland<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/mark-hedger\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Mark Hedger<\/span><\/a><\/li>\n                                                            <\/ul>\n                        <\/div>\n                                    <\/div>\n            <\/div>\n            \n            <div class=\"faq w-full flex flex-col bg-white border-b-4 border-pink-500 shadow-lg-center mb-2\">\n                <div class=\"faq__question group relative py-4 pl-4 pr-16 sm:py-6 sm:pl-6 sm:pr-16 cursor-pointer\" data-target=\"block_3952762594e511decb33f7069055363e-answer-4\">\n                    <h3 class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" class=\"text-lg sm:text-xl font-bold text-blue-800 leading-tight group-hover:text-blue-500\" id=\"the-foundations-of-testis-growth-steroids-in-the-fetal-testis\">The foundations of testis growth: Steroids in the fetal testis<\/h3>\n                    <img decoding=\"async\" src=\"https:\/\/hudson.org.au\/wp-content\/themes\/hudson-au\/img\/arrow-down--pink.svg\" class=\"faq__arrow absolute w-auto h-3 transform transition-transform duration-300 -rotate-90\" style=\"top: calc(50% - (.75rem \/ 2)); right: 1.5rem;\" \/>\n                <\/div>\n                <div id=\"block_3952762594e511decb33f7069055363e-answer-4\" class=\"faq__answer cms-content px-4 sm:px-6 pb-4 sm:pb-6 hidden\">\n                    <div class=\"cms-content\">\n                        <p><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-23567 alignleft\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg\" alt=\"Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute\" width=\"150\" height=\"150\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-150x150.jpg 150w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-1000x1000.jpg 1000w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-320x320.jpg 320w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-400x400.jpg 400w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<p>Soon after the testes form in the male fetus, testosterone is produced to masculinise the embryo, affecting growth of the brain and other organs, as well as penis formation. Professor Loveland\u2019s group discovered that activin A is directly responsible for driving testosterone production in the testes growing in the womb. It promotes synthesis of two enzymes crucial for the final steps of testosterone synthesis. The absence of activin A resulted in an abnormal steroid environment during a window of development when the program of masculinisation is initiated in male offspring.<\/p>\n                    <\/div>\n\n                                            <div class=\"related_researchers\">\n                            <ul class=\"flex flex-wrap mt-4 -mb-1\">\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/penny-whiley\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Penny Whiley Ph.D.<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Professor Kate Loveland<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/liza-odonnell\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Dr Liza O\u2019Donnell<\/span><\/a><\/li>\n                                                                    <li class=\"inline-flex mr-1 mb-1\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/jennifer-hutchison\/\" class=\"px-4 py-2 bg-pink-500 leading-none text-sm text-white rounded-full\" target=\"_blank\"><span class=\"staff-full-name\">Dr Jennifer Hutchison<\/span><\/a><\/li>\n                                                            <\/ul>\n                        <\/div>\n                                    <\/div>\n            <\/div>\n                <\/div>\n\n\n<\/div>\n    <\/div>\n<\/div>\n\n\n\n<div class=\"bd-grid-container__column flex w-full col-span-4 sm:col-span-4            \">\n    <div class=\"w-full wp-block-bd-grid-container-column\">\n        <div class=\"grid-container-column__innerblocks cms-content\n                            \">\n\n<h4 class=\"wp-block-heading has-text-align-left\" id=\"h-testicular-cancer-collaborators\">Testicular cancer collaborators<\/h4>\n\n\n\n<p><a href=\"https:\/\/aua.com.au\/about-us\/our-urologists\/professor-mark-frydenberg\/\" target=\"_blank\" rel=\"noreferrer noopener\">Australian Urology Associates: Professor Mark Frydenberg<\/a>,  <a href=\"https:\/\/www.uni-giessen.de\/en\" target=\"_blank\" rel=\"noreferrer noopener\">Justus-Liebig University<\/a> &#8211; <a href=\"https:\/\/www.researchgate.net\/profile\/Daniela-Fietz\" target=\"_blank\" rel=\"noreferrer noopener\">Daniela Fietz<\/a>, <a href=\"https:\/\/www.ukgm.de\/home.html\" target=\"_blank\" rel=\"noreferrer noopener\">Uniklinikum Giessen und Marburg<\/a> &#8211; <a href=\"https:\/\/www.ukgm.de\/ugm_2\/deu\/ugi_uro\/ugi_uro_team.php?id=1711\" target=\"_blank\" rel=\"noreferrer noopener\">Hans-Christian Schuppe<\/a>, <a href=\"https:\/\/www.petermac.org\/users\/dr-ben-tran\" target=\"_blank\" rel=\"noreferrer noopener\">Peter MacCallum Cancer Centre &#8211; Ben Tran<\/a>, <a href=\"https:\/\/www.utah.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Utah<\/a> &#8211; <a href=\"https:\/\/medicine.utah.edu\/faculty\/mddetail.php?facultyID=u0892036\" target=\"_blank\" rel=\"noreferrer noopener\">Jingtao Guo<\/a>, <a href=\"https:\/\/healthcare.utah.edu\/fad\/mddetail.php?physicianID=u0908993&amp;name=james-m-hotaling\">Jim Hotaling<\/a>, <a href=\"https:\/\/www.ku.dk\/en\" target=\"_blank\" rel=\"noreferrer noopener\">University of Copenhagen<\/a> &#8211; Ewa <a href=\"https:\/\/research.regionh.dk\/rigshospitalet\/en\/persons\/ewa-rajpertde-meyts(e01817cf-6245-4bb1-ab72-c2921c3696a7).html\">Rajpert-De Meyts<\/a>, <a href=\"https:\/\/research.regionh.dk\/rigshospitalet\/en\/persons\/kristian-almstrup(aadcd56e-0a89-4588-b0b9-929106cc9d16).html\">Kristian Almstrup<\/a>, <a href=\"https:\/\/research.regionh.dk\/\">Anne Jorgensen<\/a><\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-text-align-left\" id=\"h-support-for-people-with-testicular-cancer\">Support for people with testicular cancer<\/h4>\n\n\n\n<p class=\"has-text-align-left\">Hudson Institute scientists cannot provide medical advice.<\/p>\n\n\n\n<p class=\"has-text-align-left\">If you would like to find out more information about testicular cancer, please visit<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/au.movember.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Movember<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.healthymale.org.au\" target=\"_blank\" rel=\"noreferrer noopener\">Healthy Male<\/a><\/li>\n<\/ul>\n\n<\/div>\n    <\/div>\n<\/div>\n\n<\/div>\n    <\/div>\n<\/div>\n\n\n\n            <div class=\"block-impact max-w-screen bg-white \">\n                <div class=\"relative z-10 py-12\">\n                    <div class=\"hn-container w-full mx-auto px-3 md:px-7 xl:px-11 block\">\n                        <div class=\"relative mb-4\">\n                            <h2 class=\"font-bold text-2xl md:text-3xl text-blue-800 text-center\" class=\"font-bold text-2xl md:text-3xl text-blue-800 text-center\" id=\"testicular-cancer-news\">Testicular cancer news<\/h2>\n                        <\/div>\n                        <div class=\"slick-slider slick-slider--impact flex relative w-full max-w-full\">\n                            \n                                <a href=\"https:\/\/hudson.org.au\/news\/male-fertility-and-testicular-cancer\/\" class=\"group relative flex flex-col w-1\/5 h-full bg-white mx-1 hover:bg-pink-500 transition duration-200\">\n                 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male fertility and testicular cancer causes<\/h3>\n                                        <svg class=\"absolute w-3 h-auto fill-current text-pink-500 group-hover:text-white\" style=\"left: 1rem; bottom: 1rem;\" viewBox=\"0 0 11 17.4\" xml:space=\"preserve\">\n                                            <g>\n                                                <path d=\"M1,17.4c-0.3,0-0.5-0.1-0.7-0.3c-0.4-0.4-0.3-1,0.1-1.4l7.7-7l-7.7-7c-0.4-0.4-0.4-1-0.1-1.4\n                                                    c0.4-0.4,1-0.4,1.4-0.1L11,8.7l-9.4,8.4C1.5,17.3,1.2,17.4,1,17.4z\"\/>\n                                            <\/g>\n                                        <\/svg>\n                                    <\/div>\n                                <\/a>\n                                \n                                <a href=\"https:\/\/hudson.org.au\/news\/rising-male-infertility-and-testicular-cancer-rates-linked-to-protein\/\" class=\"group relative flex flex-col w-1\/5 h-full bg-white mx-1 hover:bg-pink-500 transition duration-200\">\n                                    <div class=\"relative w-full flex-shrink-0 bg-gray-800 bg-cover bg-center h-0\" style=\"padding-top: 100%; background-image: url('https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/07\/Sarah-and-Kate-400x400.jpg')\">\n                                                                            <\/div>\n                                    <div class=\"relative h-full p-4 pb-8\">\n                                        <time datetime=\"2020-07-13\" class=\"block text-sm leading-tight mb-1 group-hover:text-white\">13 July 2020<\/time>\n                                        <h3 class=\"text-xl text-blue-700 font-bold leading-tight mb-6 group-hover:text-white\" style=\"margin-top: 0; margin-bottom: 1.5rem;\" class=\"text-xl text-blue-700 font-bold leading-tight mb-6 group-hover:text-white\" style=\"margin-top: 0; margin-bottom: 1.5rem;\" id=\"infertility-and-testicular-cancer-linked-to-protein-in-pregnancy\">Infertility and testicular cancer linked to protein in pregnancy<\/h3>\n                                        <svg class=\"absolute w-3 h-auto fill-current text-pink-500 group-hover:text-white\" style=\"left: 1rem; bottom: 1rem;\" viewBox=\"0 0 11 17.4\" xml:space=\"preserve\">\n                                            <g>\n                                                <path d=\"M1,17.4c-0.3,0-0.5-0.1-0.7-0.3c-0.4-0.4-0.3-1,0.1-1.4l7.7-7l-7.7-7c-0.4-0.4-0.4-1-0.1-1.4\n                                                    c0.4-0.4,1-0.4,1.4-0.1L11,8.7l-9.4,8.4C1.5,17.3,1.2,17.4,1,17.4z\"\/>\n                                            <\/g>\n                                        <\/svg>\n                                    <\/div>\n                                <\/a>\n                                \n                                <a href=\"https:\/\/hudson.org.au\/news\/male-reproductive-health-problems-could-begin-in-the-womb\/\" class=\"group relative flex flex-col w-1\/5 h-full bg-white mx-1 hover:bg-pink-500 transition duration-200\">\n                                    <div class=\"relative w-full flex-shrink-0 bg-gray-800 bg-cover bg-center h-0\" style=\"padding-top: 100%; background-image: url('https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/04\/Penny-and-Kate_LP-400x400.jpg')\">\n                                                                            <\/div>\n                                    <div class=\"relative h-full p-4 pb-8\">\n                                        <time datetime=\"2020-04-23\" class=\"block text-sm leading-tight mb-1 group-hover:text-white\">23 April 2020<\/time>\n                                        <h3 class=\"text-xl text-blue-700 font-bold leading-tight mb-6 group-hover:text-white\" style=\"margin-top: 0; margin-bottom: 1.5rem;\" class=\"text-xl text-blue-700 font-bold leading-tight mb-6 group-hover:text-white\" style=\"margin-top: 0; margin-bottom: 1.5rem;\" id=\"male-reproductive-health-problems-could-begin-in-the-womb\">Male reproductive health problems could begin in the womb<\/h3>\n                                        <svg class=\"absolute w-3 h-auto fill-current text-pink-500 group-hover:text-white\" style=\"left: 1rem; bottom: 1rem;\" viewBox=\"0 0 11 17.4\" xml:space=\"preserve\">\n                                            <g>\n                                                <path d=\"M1,17.4c-0.3,0-0.5-0.1-0.7-0.3c-0.4-0.4-0.3-1,0.1-1.4l7.7-7l-7.7-7c-0.4-0.4-0.4-1-0.1-1.4\n                                                    c0.4-0.4,1-0.4,1.4-0.1L11,8.7l-9.4,8.4C1.5,17.3,1.2,17.4,1,17.4z\"\/>\n                                            <\/g>\n                                        <\/svg>\n                                    <\/div>\n                                <\/a>\n                                                      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url('https:\/\/hudson.org.au\/wp-content\/uploads\/2023\/05\/kate-loveland-profile-2026.jpg');\"><\/div>\n                                    <div class=\"w-100 p-4\">\n                                        <h3 class=\"text-2xl text-blue-500 leading-tight\" class=\"text-2xl text-blue-500 leading-tight\" id=\"professor-kate-loveland\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"hover:text-pink-500\"><span class=\"staff-full-name\">Professor Kate Loveland<\/span><\/a><\/h3>\n                                        <p class=\"text-base leading-tight mb-2\"><a href=\"https:\/\/hudson.org.au\/research-group\/testis-development-and-male-germ-cell-biology\/\" class=\"hover:text-pink-500\">Testis Development and Male Germ Cell Biology<\/a><\/p>\n                                        <p class=\"text-base leading-tight\"><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\" class=\"text-blue-800 border-b border-blue-800 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Younger men, aged between 20 and 40 years, have the highest risk&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/disease\/cancer\/testicular-cancer\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":36263,"parent":33784,"menu_order":22,"template":"","class_list":["post-36917","disease","type-disease","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Testicular cancer - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Testicular cancer is rising, for unknown reasons. 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