{"id":33289,"date":"2020-08-27T08:22:07","date_gmt":"2020-08-26T22:22:07","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&#038;p=33289"},"modified":"2025-06-25T16:01:22","modified_gmt":"2025-06-25T06:01:22","slug":"male-fertility-and-testicular-cancer","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/male-fertility-and-testicular-cancer\/","title":{"rendered":"More clues discovered to male fertility and testicular cancer causes"},"content":{"rendered":"\n<p class=\"intro has-medium-font-size\">A discovery by Hudson Institute researchers has shed more light on the causes of <a href=\"https:\/\/hudson.org.au\/disease\/cancer\/testicular-cancer\/\">testicular cancer<\/a> and <a href=\"https:\/\/hudson.org.au\/disease\/womens-newborn-health\/infertility\/\">male infertility<\/a> \u2013 and provided a potential new target for treatment.<\/p>\n\n\n<div class=\"wp-block-image size-medium wp-image-23567\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"296\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-300x296.jpg\" alt=\"Professor Kate Loveland from the Testis Development and Male Germ Cell Biology Research Group at Hudson Institute sheds more light on the causes of testicular cancer and male infertility.\" class=\"wp-image-23567\" srcset=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-300x296.jpg 300w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-768x758.jpg 768w, https:\/\/hudson.org.au\/wp-content\/uploads\/2018\/11\/194_Kate-Loveland_20180215-e1542604370845-1024x1011.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-element-caption\"><em>Professor Kate Loveland<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><a href=\"https:\/\/hudson.org.au\/researcher-profile\/kate-loveland\/\">Professor Kate Loveland<\/a> said the discovery has important implications for boosting male fertility, and for treating men with testicular cancer, especially those who experience a relapse and poor prognosis.<\/p>\n\n\n\n<p>The study is the first to document the importance of a cell signalling pathway\u2014crucial for embryonic development\u2014to male fertility and testis cancer.<\/p>\n\n\n\n<p>Lead researcher, Prof Loveland said the pathway\u2014called WNT signalling\u2014plays an active role during sperm development, and is also present in precursor tumour cells that turn into cancerous cells.<\/p>\n\n\n\n<p>Prof Loveland said the discovery, published in the journal <a href=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/08\/2020-WNT-in-hTestis-TCa-Young-HumReprod.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Andrology<\/a>, was crucial to better understand rising infertility and testicular cancer rates, and developing treatments to combat these.<\/p>\n\n\n\n<p>\u201cDiscovering the fundamental processes required to make healthy sperm is essential knowledge for reversing the increasing frequency of infertility and testicular cancer,\u201d Prof Loveland said.<\/p>\n\n\n\n    <div class=\"block--callout flex z-20 text-blue-800 bg-gray-100 p-6 mb-5 sm:mb-8 w-full\">\n        <div class=\"cms-content\">\n            <h2 id=\"facts\">Facts<\/h2>\n<ul>\n<li>Infertility affects one in 20 Australian couples<\/li>\n<li>Half of cases attributed to the male partner, often with an unknown cause<\/li>\n<li>One in 25 Australian babies are conceived by IVF.<\/li>\n<li>Testicular cancers from reproductive cells are the most common solid tumour type found in young men aged 19 to 44<\/li>\n<li>This type of cancer has been increasing by two per cent a year for the past 50 years.<\/li>\n<\/ul>\n        <\/div>\n    <\/div>\n\n    \n\n\n<p><\/p>\n\n\n\n<p>Prof Loveland said the discovery provided the opportunity to test treatment drugs that act on this pathway, to help boost fertility or block testicular tumour development.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cOur studies in the lab provide evidence that blocking this pathway should be evaluated to reduce growth and proliferation of testicular cancer cells,\u201d Prof Loveland said.<\/p>\n\n\n\n<p>\u201cMost young men \u2013 95 per cent \u2013 who get testicular germ cell (reproductive) tumours can be \u2018cured\u2019 with surgery and chemotherapy, but the prognosis is poor for men who relapse,\u201d she said.<\/p>\n\n\n\n<p>\u201cThis study is the first to document the importance of WNT signalling to human male fertility and testis cancer.&nbsp; We are investigating this further in collaboration with our international and local clinical partners.\u201d<\/p>\n<\/blockquote>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A discovery by Hudson Institute researchers has shed more light on the causes of testicular cancer and male infertility \u2013 and provided a potential new target for treatment.&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/news\/male-fertility-and-testicular-cancer\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":23567,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[],"class_list":["post-33289","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>More clues discovered to male fertility and testicular cancer causes - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Hudson Institute of Medical Research study sheds more light on testicular cancer causes and male 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