{"id":31620,"date":"2020-04-29T12:00:33","date_gmt":"2020-04-29T02:00:33","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&#038;p=31620"},"modified":"2024-02-19T15:44:07","modified_gmt":"2024-02-19T04:44:07","slug":"hyper-acute-inflammation-in-covid-19","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/hyper-acute-inflammation-in-covid-19\/","title":{"rendered":"Hyper-acute inflammation in COVID-19"},"content":{"rendered":"\n<p class=\"intro has-medium-font-size\">Sepsis is a hyper-acute inflammatory response leading to life-threatening organ dysfunction.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><a href=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/04\/CIIID-Gantier-Cytoplasmic-Foci.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"284\" height=\"204\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/04\/CIIID-Gantier-Cytoplasmic-Foci.jpg\" alt=\"Hyper-acute inflammation in COVID-19 image | The nuclei of mouse fibroblasts treated with a low dose of a chemotherapy drug for 2 days. The vesicles contain damaged DNA (revealed by the green and red overlay).\" class=\"wp-image-31175\"\/><\/a><figcaption class=\"wp-element-caption\"><em>The nuclei of mouse fibroblasts treated with a low dose of a chemotherapy drug for 2 days. The vesicles contain damaged DNA (revealed by the green and red overlay). <\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"p1\">Sepsis is usually caused by bacterial infections; however, the <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/covid-19\/\">COVID-19<\/a> pandemic illustrates that hyper-acute inflammation can also be part of viral infections. Many critical COVID-19 patients develop dangerous levels of hyper-acute inflammation, and this is associated with a high death rate.<\/p>\n\n\n\n<p class=\"p1\">The Nucleic Acids and Innate Immunity research group, headed by <a href=\"https:\/\/hudson.org.au\/researcher-profile\/michael-gantier\/\">Dr Michael Gantier<\/a>, is looking for treatments to help prevent chronic and hyper-acute inflammation.<\/p>\n\n\n\n<p class=\"p1\">Nucleic acids are the root cause of toxic inflammation in chronic diseases like lupus, or acute sepsis. This team is working with potential drugs targeting inflammation driven by nucleic acids, by validating the anti-inflammatory properties of these drugs in preclinical models of sepsis and chronic inflammation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-how-we-are-tackling-acute-inflammation\"><strong>How we are tackling acute inflammation<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Selection of molecules that can be quickly repurposed as anti-inflammatory drugs to prevent chronic inflammation and sepsis<\/li>\n\n\n\n<li>Development of new treatments that build on \u2018good\u2019 inflammation to help the body\u2019s immune system successfully fight pathogens and cancer<\/li>\n\n\n\n<li>Understanding how chronic inflammation driven by nucleic acids controls cancer development.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-do-we-need-to-research-life-threatening-inflammation\"><strong>Why do we need to research life-threatening inflammation?<\/strong><\/h3>\n\n\n\n<p class=\"p1\">\u201cIt is clear that the world is not prepared to deal with the number of ARDS patients generated by COVID-19,\u201d Dr Gantier said.<\/p>\n\n\n\n<p class=\"p1\">The body\u2019s immune response to some infections can be toxic to patients, damaging major organs. This triggers a chain of responses that can ultimately result in organ failure and death.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cIn critical COVID-19 patients, the progression from ARDS to death directly relates to out-of-control inflammation from damaged tissues,\u201d Dr Gantier said. \u201cThis progression is slow (over a week), allowing a window of opportunity to prevent the inflammatory storm and protect these patients. This is a primary focus for us.\u201d<\/p>\n<\/blockquote>\n\n\n\n    <div class=\"block--callout flex z-20 text-blue-800 bg-gray-100 p-6 mb-5 sm:mb-8 w-full\">\n        <div class=\"cms-content\">\n            <p><strong>Funders | <\/strong>Further funding is needed to pursue research into validating the drugs identified by this lab, to treat diseases driven by chronic and acute inflammation.<\/p>\n        <\/div>\n    <\/div>\n\n    \n\n\n            <div class=\"inline-block-disease-snackbar bg-blue-100 border-l-4 border-pink-500 my-5 sm:my-8\">\n                <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/covid-19\/\" class=\"flex flex-col md:flex-row\">\n                    <div class=\"w-full md:w-1\/4\">\n                        \n                            <img decoding=\"async\" class=\"block object-cover w-full\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/10\/coronavirus-2square-440x375.jpg\">\n                                            <\/div>\n                    <div class=\"flex flex-col justify-center w-full md:w-3\/4 p-4 xl:p-8\">\n                        <p class=\"uppercase font-black text-pink-500 text-base sm:text-lg mb-0\">Diseases we research<\/p>\n                        <p class=\"text-blue-700 hover:text-pink-500 text-xl sm:text-2xl xl:text-3xl font-bold\">\n                            <span class=\"inline\">COVID-19 | Learn more<\/span>\n                            <svg class=\"inline ml-1 h-4 sm:h-6 align-center text-pink-500 fill-current\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"15 0 24 34.78\">\n                                <polygon points=\"19.17 34.78 16.27 31.66 31.63 17.39 16.27 3.11 19.17 0 37.87 17.39 19.17 34.78\"><\/polygon>\n                            <\/svg>\n                        <\/p>\n                    <\/div>\n                <\/a>\n            <\/div>\n        \n\n\n            <div class=\"inline-block-disease-snackbar bg-blue-100 border-l-4 border-pink-500 my-5 sm:my-8\">\n                <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/lupus\/\" class=\"flex flex-col md:flex-row\">\n                    <div class=\"w-full md:w-1\/4\">\n                        \n                            <img decoding=\"async\" class=\"block object-cover w-full\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2021\/04\/lupus-image-generated-by-chatgpt-image-jan-5-2026-04-48-06-pm-440x375.png\">\n                                            <\/div>\n                    <div class=\"flex flex-col justify-center w-full md:w-3\/4 p-4 xl:p-8\">\n                        <p class=\"uppercase font-black text-pink-500 text-base sm:text-lg mb-0\">Diseases we research<\/p>\n                        <p class=\"text-blue-700 hover:text-pink-500 text-xl sm:text-2xl xl:text-3xl font-bold\">\n                            <span class=\"inline\">Lupus | Learn more<\/span>\n                            <svg class=\"inline ml-1 h-4 sm:h-6 align-center text-pink-500 fill-current\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"15 0 24 34.78\">\n                                <polygon points=\"19.17 34.78 16.27 31.66 31.63 17.39 16.27 3.11 19.17 0 37.87 17.39 19.17 34.78\"><\/polygon>\n                            <\/svg>\n                        <\/p>\n                    <\/div>\n                <\/a>\n            <\/div>\n        \n\n\n        <div class=\"hn-footer-promo\">\n            <div class=\"hn-footer-promo__message\">\n                <p>Help our researchers discover new treatments to save the lives of the most vulnerable COVID-19 patients.<\/p>\n            <\/div>\n            <div class=\"hn-footer-promo__button\">\n                <a href=\"https:\/\/donate.hudson.org.au\/donations\/\" target=\"_blank\">Donate now<\/a>\n            <\/div>\n        <\/div>\n        \n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-contact-us\">Contact us<\/h4>\n\n\n\n<p>Hudson Institute communications<br><strong>t:<\/strong>\u00a0+ 61 3 8572 2761<br><strong>e:<\/strong>\u00a0<a href=\"mailto:communications@hudson.org.au\" target=\"_blank\" rel=\"noreferrer noopener\">communications@hudson.org.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sepsis is a hyper-acute inflammatory response leading to life-threatening organ dysfunction. Sepsis is usually caused by bacterial infections; however, the COVID-19 pandemic illustrates that hyper-acute inflammation can also be part of viral infections.&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/news\/hyper-acute-inflammation-in-covid-19\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":31026,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[],"class_list":["post-31620","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hyper-acute inflammation in COVID-19 - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Many critical COVID-19 patients develop dangerous levels of hyper-acute inflammation, and this is associated with a high death rate.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/hyper-acute-inflammation-in-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hyper-acute inflammation in COVID-19\" \/>\n<meta property=\"og:description\" content=\"Many critical COVID-19 patients develop dangerous levels of hyper-acute inflammation, and this is associated with a high death rate.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/hyper-acute-inflammation-in-covid-19\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-19T04:44:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/04\/Michael-Gantier-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2256\" \/>\n\t<meta property=\"og:image:height\" content=\"2256\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/hyper-acute-inflammation-in-covid-19\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/hyper-acute-inflammation-in-covid-19\\\/\",\"name\":\"Hyper-acute inflammation in COVID-19 - 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