{"id":29302,"date":"2019-12-10T08:14:27","date_gmt":"2019-12-09T21:14:27","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&p=29302"},"modified":"2025-06-25T15:36:01","modified_gmt":"2025-06-25T05:36:01","slug":"nhmrc-ideas-grant-success","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/nhmrc-ideas-grant-success\/","title":{"rendered":"NHMRC Ideas Grant success"},"content":{"rendered":"\r\n

Hudson Institute has had outstanding success in the NHMRC Ideas Grant round. Our researchers have been awarded nine NHMRC Ideas Grants, totalling almost $8.5 million.<\/p>\r\n\r\n\r\n\r\n

Ideas Grants fund innovative and creative health and medical research from discovery to implementation. Congratulations to the researchers and their teams. Their research will improve the understanding, prevention and treatment of a range of Australian and global health challenges.<\/p>\r\n\r\n\r\n\n

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Role of A1 in repressing mitochondrial apoptosis to limit pathogen clearance<\/h3>\n \n

Dr Kate Lawlor<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132022<\/p>\n <\/div>\n

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Amount: $789,536<\/p>\n <\/div>\n <\/div>\n

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Macrophages detect pathogens to trigger an appropriate inflammatory response. However, many pathogens have evolved mechanisms to evade the immune system, such as the up-regulation of host pro-survival proteins. This project will investigate which pro-survival proteins limit inflammation<\/a> upon pathogen signaling, and how activation of macrophage cell death impacts the clearance of life-threatening bacterial and viral infections.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Inflammation<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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A new strategy in the search for treatments for early onset preeclampsia<\/h3>\n \n

Professor Guiying Nie<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $851,840<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Sarah Catt<\/p>\n <\/div>\n <\/div>\n

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Preeclampsia (PE) is a life-threatening disorder of pregnancy. The only current effective treatment is to deliver the baby, often prematurely<\/a>. The causes of PE are intrinsically linked to the placenta, the organ connecting the fetus to the mother and nourishing the fetus in the womb. This project focuses on an enzyme that is produced only by the placenta. The team will investigate how this enzyme, which is altered in PE, contributes to the disease and its potential as a target for treatment.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n\r\n\r\n\n

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Developmental events affecting male fertility and reproductive pathologies<\/h3>\n \n

Professor Kate Loveland<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $1,430,398<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Ewa Rajpert-De Meyts, Hans-Christian Schuppe, Andreas Meinhardt, Kristian Almstrump, Anne Jorgensen, Jingtao Guo<\/p>\n <\/div>\n <\/div>\n

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This international research collaboration explores how the testis forms and functions normally, and applies this knowledge to understand how the most common testicular pathology of young men, testicular germ cell tumours, arise.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Infertility<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Reducing the risk of pulmonary hypertension in infants with a congenital diaphragmatic hernia<\/h3>\n \n

Dr Kelly Crossley<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $920,075<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Philip DeKoninck, Ryan Hodges, Marta Thio<\/p>\n <\/div>\n <\/div>\n

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Congenital diaphragmatic hernia is a birth defect associated with abnormal development of the airways and blood vessels in the lungs. For these babies, their lungs are often too small for adequate gas exchange and many of these babies will not survive after birth. The team are investigating new ways of supporting these infants immediately after birth in order to prevent complications that are important factors for survival<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Women’s and Newborn health<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Treating inflammation in the male reproductive tract<\/h3>\n \n

Professor Mark Hedger<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132024<\/p>\n <\/div>\n

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Amount: $1,225,116<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Andreas Meinhardt<\/p>\n <\/div>\n <\/div>\n

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Excessive inflammation, which is caused by infection, trauma or spontaneous immune dysfunction can produce damage in most organs, leading to potentially severe, life-long health problems. This research examines the contribution of proteins, called activins, to the onset of inflammation in the male reproductive tract. A naturally-occurring activin-blocking protein, called follistatin, will be examined to determine if this can be a novel therapy for male reproductive disorders.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Inflammation<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Finding the balance\u2014reducing inflammation during severe influenza infections<\/h3>\n \n

Dr Michelle Tate<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132022<\/p>\n <\/div>\n

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Amount: $581,520<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Ashley Mansell<\/p>\n <\/div>\n <\/div>\n

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Highly pathogenic influenza<\/a> A virus infections are associated with high mortality rates. There is a critical need to find new drugs to reduce this impact of flu on the community. This project will identify drugs that have previously been shown to be safe in humans, that can be used to reduce damaging inflammation and mortality associated with severe influenza infections.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Influenza<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Microbiome derived candidates to revolutionise treatment of inflammatory bowel disease<\/h3>\n \n

Dr Sam Forster<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $997,926<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Edward Giles<\/p>\n <\/div>\n <\/div>\n

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Inflammatory bowel disease (IBD)<\/a> incidence is increasing worldwide. It affects more than 100,000 Australians, costing more than $3 billion per year. The team have developed a new way of taking samples from the gut and looking at the bacteria within normal and damaged gut tissue. Importantly, they have found promising bacteria to develop as a new way to treat or even cure IBD in the near future.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Inflammatory bowel disease (IBD)<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Advancing women\u2019s urogynecological health using micro\/nanotechnologies<\/h3>\n \n

Dr Shayanti Mukherjee<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $1,168,385<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Jerome Werkmeister, Bayden Wood, Anna Rosamilia<\/p>\n <\/div>\n <\/div>\n

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Pelvic organ prolapse (POP)<\/a> is a hidden, debilitating gynaecological disorder affecting 25 per cent of women causing sexual, bladder and bowel dysfunction. POP is the herniation of the uterus, bladder, or bowel into the vagina due to childbirth injury. Surgical treatment often fails and the use of vaginal mesh has been banned due to unacceptable side effects. At present, there is no cure. The team are developing novel bioengineered therapies using stem cells and nanotechnology to repair the damaged tissue.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Pelvic organ prolapse (POP)<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n\n
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Screening for primary aldosteronism: outcomes, economics and biomarkers<\/h3>\n \n

Dr Jun Yang<\/h4>\n <\/a>\n
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NHMRC Ideas Grant: 2020\u20132023<\/p>\n <\/div>\n

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Amount: $571,199<\/p>\n <\/div>\n

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Co-investigators:<\/strong> Michael Stowasser, Grant Russell, Stella Gwini<\/p>\n <\/div>\n <\/div>\n

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Hypertension<\/a> is a major cause of strokes, blindness, heart attacks and kidney failure. Primary aldosteronism (PA) is a curable cause of hypertension. Unfortunately, PA often goes undiagnosed as most doctors do not screen for it, leading to hypertension that is difficult to control and high risk of strokes and heart attacks at a younger age. This project will find out exactly how many people in our community have PA and find new cost-effective ways to make the diagnosis earlier.<\/p>\n <\/div>\n <\/div>\n <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n\r\n\r\n\n

\n Learn more about Endocrine hypertension<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \r\n\r\n","protected":false},"excerpt":{"rendered":"

Hudson Institute has had outstanding success in the NHMRC Ideas Grant round.<\/p>\n

Our researchers have been awarded nine NHMRC Ideas Grants, totalling almost $8.5 million and a success rate of 19.1 per cent.…  Read more<\/a><\/p>\n","protected":false},"featured_media":29431,"menu_order":0,"template":"page-templates\/template-fellowships-grants.php","issue":[],"tag":[],"story-type":[87],"treatment-type":[],"class_list":["post-29302","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-award"],"acf":[],"yoast_head":"\nNHMRC Ideas Grant success - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Hudson Institute has had success in the NHMRC Ideas Grant round with nine NHMRC Ideas Grants, totalling almost $8.5 million.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/nhmrc-ideas-grant-success\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NHMRC Ideas Grant success\" \/>\n<meta property=\"og:description\" content=\"Hudson Institute has had success in the NHMRC Ideas Grant round with nine NHMRC Ideas Grants, totalling almost $8.5 million.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/nhmrc-ideas-grant-success\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-25T05:36:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2019\/11\/Grants-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2000\" \/>\n\t<meta property=\"og:image:height\" content=\"1999\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/nhmrc-ideas-grant-success\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/nhmrc-ideas-grant-success\\\/\",\"name\":\"NHMRC Ideas Grant success - 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