{"id":26565,"date":"2019-05-28T10:41:08","date_gmt":"2019-05-28T00:41:08","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&p=26565"},"modified":"2022-01-20T15:09:24","modified_gmt":"2022-01-20T04:09:24","slug":"mutation-offers-holy-grail-to-combat-inflammation","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/mutation-offers-holy-grail-to-combat-inflammation\/","title":{"rendered":"Mutation offers Holy Grail to combat inflammation"},"content":{"rendered":"\n

The discovery of a human mutation that controls inflammation<\/a> could lead to improved treatments for infectious diseases. Potentially, this could improve health outcomes worldwide for diseases such as bacterial infections, septic shock, or common colds and flu<\/a>.<\/p>\n\n\n\n

The mutation comes from a practical but little-known protein, Mal, and could help our immune system achieve the elusive \u2018Goldilocks effect\u2019, a response that is \u2018not too hot, not too cold \u2013 but just right\u2019.<\/p>\n\n\n\n

When the immune system, our first line of defence, recognises infection, it produces inflammation to protect us from, then clear, the bacteria or virus. While inflammation is necessary, too much can lead to auto-immune disease or even death; while too little can result in an ineffective immune response, increasing disease and causing severe illness or even death.<\/p>\n\n\n\n

\"A\/Prof
    A\/Prof Ashley Mansell<\/em><\/figcaption><\/figure><\/div>\n\n\n\n

A study from Associate Professor Ashley Mansell<\/a>, published in the\u00a0Journal of Immunology<\/em>, shows targeting Mal would help the immune system deliver a balanced, optimal response.<\/p>\n\n\n\n

In the study, researchers were able to show that the mutation in Mal, found in fewer than three per cent of the population, can moderate inflammation. The inflammation produced in the preclinical model was reduced by around 50 per cent, but still provided the required response to infections such as influenza and E.coli.<\/p>\n\n\n\n

\u201cLooking at mutations like Mal could provide the basis of a therapeutic target to treat infectious diseases through producing a balanced inflammatory response.<\/p>

\u201cThe perfect drug that targets inflammation will reduce, but not cut out, inflammation completely. This study suggests that through targeting Mal, this is a possibility,\u201d A\/Prof Mansell said.<\/p><\/blockquote>\n\n\n\n

<\/div>\n\n\n\n
\n
\n

Global potential<\/strong><\/h3>\n

Infectious diseases range from common disorders such as sinusitis to a sore throat, through HIV infection and Hepatitis B. They are a major global health concern.<\/p>\n

Another positive health outcome could be for the treatment of sepsis, a potentially fatal condition caused by an overactive response to infection from the immune system. More than 15,000 cases of severe sepsis are recorded in Australia and New Zealand each year. Globally, sepsis affects up to 50 million people worldwide and causes 5.3 million deaths annually<\/p>\n <\/div>\n <\/div>\n\n \n\n\n

\n \n
\n \n \n <\/div>\n
\n

Diseases we research<\/p>\n

\n Inflammation | Learn more<\/span>\n \n <\/polygon>\n <\/svg>\n <\/p>\n <\/div>\n <\/a>\n <\/div>\n \n\n\n

\n
\n

Collaborator | <\/strong>University of Massachusetts<\/p>\n <\/div>\n <\/div>\n\n \n\n\n

Contact us<\/h4>\n\n\n\n

Hudson Institute communications
t: <\/strong>+ 61 3 8572 2697
e:<\/strong> communications@hudson.org.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The discovery of a human mutation that controls inflammation could lead to improved treatments for infectious diseases. Potentially, this could improve health outcomes worldwide for diseases such as bacterial infections, septic shock, or common colds and flu.…  Read more<\/a><\/p>\n","protected":false},"featured_media":26566,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[94],"class_list":["post-26565","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery","treatment-type-immunotherapies"],"acf":[],"yoast_head":"\nMutation offers Holy Grail to combat inflammation - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"A\/Prof Ashley Mansell - Says a mutation in the Mal protein could help treat common conditions, such as influenza and bacterial diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/mutation-offers-holy-grail-to-combat-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mutation offers Holy Grail to combat inflammation\" \/>\n<meta property=\"og:description\" content=\"A\/Prof Ashley Mansell - 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