{"id":13022,"date":"2016-12-03T07:38:02","date_gmt":"2016-12-03T07:38:02","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&p=13022"},"modified":"2025-06-25T15:40:47","modified_gmt":"2025-06-25T05:40:47","slug":"10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia\/","title":{"rendered":"$10 million in NHMRC funding for research including breast cancer, asthma and fetal hypoxia"},"content":{"rendered":"\n

Hudson Institute researchers have been awarded more than $10 million in funding by the National Health and Medical Research Council (NHMRC).<\/p>\n\n\n\n

Protecting the brain against oxygen deprivation in the womb, identifying ways to halt breast tumour growth, and reducing the burden of asthma and chronic lung disease are among the projects at Hudson Institute to be funded.<\/p>\n\n\n\n

The Federal Health Minister, The Hon. Sussan Ley, announced the grants in two announcements, on Saturday (3 December) and in late October.<\/p>\n\n\n\n

Hudson Institute researchers were awarded a total of $10,156,392.<\/p>\n\n\n\n

Professor Anne Kelso, CEO of the NHMRC, Australia\u2019s foremost medical research funding body, said that the project grants, announced on Friday, would support an extraordinary breadth of research around Australia.<\/p>\n\n\n\n

\n

\u201cThey include 60 fellowships for our future research leaders, laboratory studies of the origins of disease and clinical trials of new therapies,\u201d Professor Kelso said.<\/p>\n<\/blockquote>\n\n\n\n

Hudson Institute of Medical Research Director, Professor Bryan Williams, congratulated all of the recipients, and thanked the NHMRC and the Health Minister for their support.<\/p>\n\n\n\n

Creatine \u2013 could it protect the fetal brain?<\/strong><\/h3>\n\n\n
\n
\"Associate
Associate Professor David Walker<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Associate Professor David Walker, Dr Matthew McKenzie, Professor Rodney Snow (Deakin University), Dr Hayley Dickinson, Dr Stacey J Ellery<\/a> and Dr Kirstin Elgass (Monash Medical Imaging). \u201cMitochondrial damage following fetal hypoxia or birth asphyxia: Using creatine to preserve mitochondrial function\u201d Project Grant <\/p>\n\n\n\n

There is a need for preventative therapy that can be given to a mother before she gives birth to protect her baby from \u2018oxygen starvation\u2019, or hypoxia, which can threaten the baby\u2019s brain and vital organs.<\/p>\n\n\n\n

A research project led by Associate Professor David Walker will examine whether creatine, a naturally occurring amino acid derivative, could protect the fetal brain from the damaging, and often life-long, effects of hypoxia.<\/p>\n\n\n\n

\n

\u201cWe\u2019ll determine what effect oxygen starvation has on the structure and function of mitochondria in the brain, then look at whether creatine could offer protection against the loss of fetal brain function,\u201d A\/Prof Walker said.<\/p>\n<\/blockquote>\n\n\n\n

\n Learn more about Birth asphyxia<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \n\n\n

Asthma and COPD \u2013 preventing debilitating respiratory infections<\/strong><\/h3>\n\n\n
\n
\"Professor<\/a>
Professor Philip Bardin<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Professor Philip Bardin<\/a>, Dr Michael Gantier<\/a>, Professor Jack Elias (Brown University) and Professor Kate Loveland<\/a> \u201cAttenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-\u03b2 activity\u201d Project Grant<\/p>\n\n\n\n

Asthma and chronic obstructive pulmonary disease (COPD) are two of the most prevalent respiratory diseases, and which leave sufferers vulnerable to viral and bacterial lung infections.<\/p>\n\n\n\n

A team of Hudson Institute researchers will investigate whether blocking a protein called Transforming growth factor-\u03b2 (TGFB), which drives scarring in the lungs of asthma and COPD patients, may also help to prevent bacterial and viral infections in the lungs.<\/p>\n\n\n\n

\n

\u201cThis research has the potential to significantly improve the quality of life of these patients, whilst reducing the burden of chronic lung diseases on the Australian Health Care system,\u201d Dr Belinda Thomas, Research Fellow in Hudson\u2019s Centre for Innate Immunity and Infectious Diseases, said.<\/p>\n<\/blockquote>\n\n\n\n\n\n\n

E<\/strong>AR2 \u2013 a new target for breast cancer metastasis<\/h3>\n\n\n\n

Associate Professor Colin Clyne<\/a> and Dr Kristy Brown \u201cEAR2: A novel driver of breast cancer proliferation\u201d Project Grant <\/p>\n\n\n\n

Drugs such as Tamoxifin are used to block the action of hormones such as estrogen, which drive breast cancer growth. However, what happens when these drugs don\u2019t work, or a patient invariably becomes resistant to the drug over time?<\/p>\n\n\n\n

A new NHMRC funded research project, led by Associate Professor Colin Clyne, will focus on a protein called EAR2, which is highly elevated in breast cancer tissues, and whether it is implicated in cancer growth.<\/p>\n\n\n\n

\n

\u201cIf we are correct, this will validate EAR2 as a potential new target for treatment, which will ultimately benefit patients whose cancers do not respond to, or become resistant to, hormone therapies such as Tamoxifin,\u201d A\/Prof Clyne said.<\/p>\n<\/blockquote>\n\n\n\n

\n Learn more about Cancer<\/span>\n \n <\/polygon>\n <\/svg>\n <\/a>\n <\/div>\n \n\n\n

Other highlights<\/h3>\n\n\n\n

Professor Paul Hertzog<\/a>, Dr Julian Vivian and Dr Nicole de Weerd<\/a> | \u2018Structure-function of type I interferon receptors informing the basis for selective modulation of signal transduction and function\u2019 Project Grant<\/p>\n\n\n\n

Dr Miranda Davies-Tuck<\/a> | \u2018A double randomised controlled trial of Melatonin in women undergoing induction of labour\u2019 New Investigator Project Grant<\/p>\n\n\n\n

Professor Ron Firestein<\/a>, Professor Bryan Williams<\/a>, Dr Suresh Mathivanan and Dr Jason Cain | \u2018Mediator Kinase as a therapeutic target for Wnt\/ \u03b2-catenin pathway dependent malignancies\u2019 Project Grant<\/p>\n\n\n\n

Associate Professor Evdokia (Eva) Dimitriadis and Associate Professor Luk Rombauts | \u201cFacilitating endometrial receptivity to improve pregnancy outcomes\u201d Project Grant<\/p>\n\n\n\n

Associate Professor Mark Hedger<\/a>, Professor Kate Loveland<\/a>, Professor Andreas Meinhardt and Associate Professor Ashley Mansell<\/a> | \u2018Regulation of immune responses in the adult testis and male reproductive health\u2019 Project Grant<\/p>\n\n\n\n

Dr Peter Stanton<\/a>, Associate Professor Craig Harrison<\/a>, Associate Professor Mark Hedger<\/a> and Professor Robert McLachlan<\/a> | \u2018The importance of the blood-testis barrier in human infertility\u2019 Project Grant<\/p>\n\n\n\n

\n\n\n\n

Contact us<\/h4>\n\n\n\n

Hudson Institute communications
t: <\/strong>+61 3 8572 2697
e:<\/strong> communications@hudson.org.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Hudson Institute researchers have been awarded more than $10 million in funding by the National Health and Medical Research Council (NHMRC).…  Read more<\/a><\/p>\n","protected":false},"featured_media":13027,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[87],"treatment-type":[],"class_list":["post-13022","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-award"],"acf":[],"yoast_head":"\n$10 million in NHMRC funding for research including breast cancer, asthma and fetal hypoxia - Hudson Institute of Medical Research<\/title>\n<meta name=\"description\" content=\"Hudson Institute researchers have been awarded more than $10 million in funding by the National Health and Medical Research Council (NHMRC).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudson.org.au\/news\/10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"$10 million in NHMRC funding for research including breast cancer, asthma and fetal hypoxia\" \/>\n<meta property=\"og:description\" content=\"Hudson Institute researchers have been awarded more than $10 million in funding by the National Health and Medical Research Council (NHMRC).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudson.org.au\/news\/10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudson Institute of Medical Research\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-25T05:40:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2016\/12\/baby.png\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"267\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia\\\/\",\"url\":\"https:\\\/\\\/hudson.org.au\\\/news\\\/10-million-in-nhmrc-funding-for-research-including-breast-cancer-asthma-and-fetal-hypoxia\\\/\",\"name\":\"$10 million in NHMRC funding for research including breast cancer, asthma and fetal hypoxia - 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