{"id":12180,"date":"2016-08-25T03:37:34","date_gmt":"2016-08-25T03:37:34","guid":{"rendered":"https:\/\/utter-drop.flywheelsites.com\/?post_type=hdsn_news_post&#038;p=12180"},"modified":"2022-02-09T12:24:09","modified_gmt":"2022-02-09T01:24:09","slug":"researchers-identify-protein-to-prevent-damage-to-donated-vital-organs-2","status":"publish","type":"hdsn_news_post","link":"https:\/\/hudson.org.au\/news\/researchers-identify-protein-to-prevent-damage-to-donated-vital-organs-2\/","title":{"rendered":"Researchers identify protein to prevent damage to donated vital organs"},"content":{"rendered":"\n<p class=\"has-medium-font-size\">Melbourne researchers have identified a protein (follistatin) that could prevent damage to donated organs before and after transplantation, and potentially stop the body rejecting them.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-medium\"><a href=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2016\/08\/DDK2.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"195\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2016\/08\/DDK2-300x195.jpg\" alt=\"Professor David de Kretser - Melbourne researchers have identified a protein, follistatin, that could prevent damage to donated organs before and after transplantation.\" class=\"wp-image-10795\"\/><\/a><figcaption><em>Professor David de Kretser<\/em><\/figcaption><\/figure><\/div>\n\n\n\n<p>At any given time, 1500 Australians are on the waiting list for an organ transplant and many of these transplants fail after a short period of time. The discovery could prove crucial to the thousands of Australians who require an organ due to injury or disease.<\/p>\n\n\n\n<p>The collaborative study, involving researchers from Hudson Institute of Medical Research, Monash University, St Vincent\u2019s Hospital and the University of Melbourne has just been published in the journal, <em>Transplantation Direct<\/em>.<\/p>\n\n\n\n<p>Donated organs are deprived of their blood supply and oxygen during transplantation, before they are reconnected to the blood supply of the recipient.\u00a0 This results in <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/\">inflammation<\/a>, which can cause permanent damage to the organ. The scientists showed that follistatin markedly reduces this inflammation, providing better outcomes for the patient.<\/p>\n\n\n\n<p>Co-investigator, <a href=\"https:\/\/hudson.org.au\/researcher-profile\/david-de-kretser\/\">Professor David de Kretser<\/a> from the Hudson Institute of Medical Research and Monash University in Melbourne, is also a Director of Paranta Biosciences, a company that developed follistatin, a protein with anti-inflammatory and anti-fibrotic properties for clinical use.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cFollistatin is a naturally occurring protein found in almost every organ in the body. We have shown that follistatin works by blocking the actions of another protein called activin, a key initiator of the inflammatory response,\u201d Professor de Kretser said.<\/p><\/blockquote>\n\n\n\n<p>\u201cDuring an organ transplant, follistatin decreases the inflammation caused by the restoration of the blood supply to the transplanted organ, halting or preventing a process called ischemia-reperfusion injury (IRI),\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cIRI causes the release activin, which causes the inflammation and the fibrosis or scarring that follows. The scarring impairs the function of the transplanted organ to varying degrees.\u201d<\/p><\/blockquote>\n\n\n\n<p>The team showed that the use of follistatin during kidney transplants in pre-clinical models reduced the damage that would have otherwise resulted in kidney failure.<\/p>\n\n\n\n<p>Paranta Biosciences is discussing the use of follistatin as a valuable additive to solutions that preserve the function of organs during transplantation with companies who produce these products.<\/p>\n\n\n\n<p>A pioneer of reproductive health research at Hudson Institute, Professor de Kretser says follistatin is well-known for its role in the body\u2019s reproductive processes, but his current work with the protein surprises even him.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cBack in 1987 , we could never have predicted that we would be working to develop follistatin as an anti-inflammatory and anti-fibrotic drug which could be used to help any type of inflammation that progresses to fibrosis, including the kidneys, liver, lungs and skin,\u201d he said.<\/p><\/blockquote>\n\n\n\n            <div class=\"inline-block-disease-snackbar bg-blue-100 border-l-4 border-pink-500 my-5 sm:my-8\">\n                <a href=\"https:\/\/hudson.org.au\/disease\/inflammation\/\" class=\"flex flex-col md:flex-row\">\n                    <div class=\"w-full md:w-1\/4\">\n                        \n                            <img decoding=\"async\" class=\"block object-cover w-full\" src=\"https:\/\/hudson.org.au\/wp-content\/uploads\/2020\/10\/coronavirus-2square-440x375.jpg\">\n                                            <\/div>\n                    <div class=\"flex flex-col justify-center w-full md:w-3\/4 p-4 xl:p-8\">\n                        <p class=\"uppercase font-black text-pink-500 text-base sm:text-lg mb-0\">Diseases we research<\/p>\n                        <p class=\"text-blue-700 hover:text-pink-500 text-xl sm:text-2xl xl:text-3xl font-bold\">\n                            <span class=\"inline\">Inflammation | Learn more<\/span>\n                            <svg class=\"inline ml-1 h-4 sm:h-6 align-center text-pink-500 fill-current\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"15 0 24 34.78\">\n                                <polygon points=\"19.17 34.78 16.27 31.66 31.63 17.39 16.27 3.11 19.17 0 37.87 17.39 19.17 34.78\"><\/polygon>\n                            <\/svg>\n                        <\/p>\n                    <\/div>\n                <\/a>\n            <\/div>\n        \n\n\n<h4 class=\"wp-block-heading\" id=\"h-contact-us\">Contact us<\/h4>\n\n\n\n<p>Hudson Institute communications<br><strong>t:&nbsp;<\/strong>+61 3 8572 2697<br><strong>e:<\/strong>&nbsp;communications@hudson.org.au<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Melbourne researchers have identified a protein (follistatin) that could prevent damage to donated organs before and after transplantation, and potentially stop the body rejecting the&hellip;&nbsp;&nbsp;<a class=\"read-more\" href=\"https:\/\/hudson.org.au\/news\/researchers-identify-protein-to-prevent-damage-to-donated-vital-organs-2\/\">Read more<\/a><\/p>\n","protected":false},"featured_media":10795,"menu_order":0,"template":"","issue":[],"tag":[],"story-type":[85],"treatment-type":[94],"class_list":["post-12180","hdsn_news_post","type-hdsn_news_post","status-publish","has-post-thumbnail","hentry","story-type-discovery","treatment-type-immunotherapies"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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